Articles of Significant Interest in This Issue

Abstract

ANP32 proteins are host factors essential for influenza virus replication. When avian influenza viruses jump into mammalian hosts, they must adapt to the ANP32 proteins present in that mammal. Pigs are sometimes considered intermediate hosts since they are susceptible to both human and avian influenza viruses. Peacock et al. (e00132-20) found that, unlike other mammalian ANP32 proteins, swine ANP32A partially supports unadapted avian influenza virus replication, explaining why swine are more susceptible to avian influenza viruses. This discovery sheds light on the ecology and evolution of influenza viruses.