Abstract
Extracellular vesicles (EVs) constitute a form of cell-to-cell communication that impacts recipient cells in a substantial manner. EVs are modified during herpes simplex virus 1 (HSV-1) infection and communicate virus specific signals. Dogrammatzis et al. (e02357-20) show that a density gradient can separate EVs from HSV-1 virions and allow dissection of different EV populations. EVs enriched in CD63 carry the stimulator of interferon genes (STING) and display an antiviral role. EVs enriched in components of the endosomal sorting complexes required for transport (ESCRT) carry viral components and display a proviral role. These data highlight the complexity of the signals infected cells communicate to uninfected cells.
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