Abstract
Akt is a key signaling protein in eukaryotic cells that influences the life cycles of viruses in a variety of ways. Owusu et al. (e01923-21) report that Akt signaling is important for optimum infection of both acute (murine norovirus 1 [MNV-1]) and persistent (CR3 and CR6) MNV strains. However, the effect of Akt on the different stages of the MNV life cycle is strain dependent, with differential effects on replication (CR3), assembly (MNV-1), and cellular egress (CR3 and CR6). The data, for the first time, indicate a role for Akt signaling in viral assembly and highlight additional phenotypic differences between closely related MNV strains.
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