Abstract
Changing nutritional conditions challenge and evolutionarily shape microbes. Sekar et al. (e00049-20) investigated the short-term metabolic response to fluctuating nutrients. Using real-time metabolomics, they found significant metabolic activity linked to the rapid utilization of intracellular glycogen. Cells capable of utilizing glycogen exhibited shorter lag times upon carbon source switches, an increased glucose uptake in fluctuating environments, and a faster switch between planktonic and biofilm phenotypes. This study highlights an underappreciated role of glycogen to rapidly provide energy in changing environments, thereby increasing survival and competition capabilities under fluctuating and nutrient-poor conditions.
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