Abstract
Human cytomegalovirus (HCMV) infection causes high rates of morbidity in immunosuppressed individuals, such as neonates and transplant recipients. It is known that viruses require host cell energy and molecular building blocks to produce successful viral progeny, and HCMV is no exception. Dunn et al. (e01321-20) show that the catalytic subunit of AMP-activated protein kinase, AMPKa2, is induced by HCMV infection and is required for critical metabolic functions that drive robust infection. These findings provide insight into how HCMV regulates cellular metabolism and highlight a potential therapeutic vulnerability for the treatment of HCMV infection.
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