Abstract
Acinetobacter baumannii is an emerging pathogen and a leading cause of hospital-acquired infections. However, many of the mechanisms utilized by this pathogen to cause disease remain poorly understood. In this issue, Green et al. (e00762-19) characterize a mechanism by which A. baumannii coordinates a response to manganese (Mn) starvation and reactive oxygen species (ROS), two stressors encountered by pathogens during infection. They find that A. baumannii Mn utilization facilitates resistance to ROS and uncover a relationship between Mn homeostasis, metabolism, and oxidative stress in this organism, highlighting the interconnectedness of these processes and exposing a promising target for antimicrobial development.
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