Abstract
Within the nucleus, there is a complicated, spatially organized environment where protein dynamics are fundamental to genome organization and regulation. Marshall et al. (e00452-19) show that the retinoblastoma (RB) protein is a recruitment factor for the chromosome architectural protein complexes condensin II and TFIIIC, particularly at small promoters between bidirectional genes. Occupancy of these architectural proteins is required to establish long-range chromosome interactions that influence gene expression at these locations. Overall, this work suggests that loss of RB may also contribute to cancer progression through altered chromosome topology and gene expression due to reduced condensin II and TFIIIC recruitment.
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