Abstract
JC polyomavirus (JCPyV) usurps serotonin 5-hydroxytryptamine (5-HT) subtype 2 (2A, 2B, and 2C) family receptors (5-HT2Rs) for entry by clathrin-mediated endocytosis. Internalization of JCPyV requires the 5-HT2R scaffolding protein β-arrestin, yet the process by which β-arrestin is recruited to 5-HT2Rs to facilitate entry remained unclear. Mayberry et al. (e02139-20) found that G protein receptor kinase 2 (GRK2) helps facilitate interactions between β-arrestin and specific β-arrestin binding motifs within 5-HT2Rs for JCPyV entry. This work further characterizes the cellular factors that promote JCPyV internalization and the resultant infection, providing improved insights into the mechanisms of infection by nonenveloped viruses.
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