Abstract
Induced gene expression in response to Notch signaling relies on a transcriptional coactivator of the mastermind-like (MAML) family, but the mechanism by which MAML recruitment results in a transcriptional response remains incompletely understood. Rogers et al. (e00014-20) show that the transcriptional response to Notch depends on a p300-interacting region of MAML, yet artificial recruitment of the p300 histone acetyltransferase domain by fusion to the Notch-binding part of MAML activates transcription of only a subset of Notch target genes. This work reveals differential requirements for MAML1-dependent recruitment activities at different Notch-responsive loci, highlighting the molecular complexity of Notch-dependent transcription.
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