Abstract
To co-opt host translational machinery and evade detection of non-self RNAs by host cells, influenza A virus (IAV) “snatches” 5′ RNA caps and short nucleotide sequences from host RNAs. Until now, scientists considered cap-snatching a random process. Clohisey et al. (e01720-19) discovered biased snatching of host RNAs, including those associated with small nuclear RNA (snRNA) transcription. They also showed that IAV avoids transcripts encoding host ribosomal proteins, which are required for viral replication. These findings provide a new perspective for this host-pathogen interaction.
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