Abstract
Streptococcus mutans and other streptococci encode a conserved ComD/E (BlpH/R) two-component signal transduction (TCS) system that modulates production of bacteriocins to inhibit competing bacterial presence in the niche. Dhaked et al. (e00330-21) showed that the response regulator ComE of this TCS senses the redox status of the environment and regulates bacteriocin production. They demonstrated that ComE alters its conformation under aerobic conditions and forms oligomers using intermolecular disulfide bonds. The ComE oligomers bind strongly to the cognate bacteriocin promoters without involving the ComD sensor kinase. This study provides a new insight into the redox sensing mechanism involving ComE in streptococci.
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