Abstract
The role of outer membrane vesicles (OMVs) in the encapsulation and delivery of small noncoding RNA (sncRNA) in the exercise of biological functions has attracted more and more attention. Li et al. (e00267-22) identified two sncRNAs encapsulated by OMVs derived from Helicobacter pylori that have the function of regulating host immunity. They show that knocking out sR-989262 and sR-2509025 improves the immunogenicity and protective efficacy of OMVs. Understanding the role of OMV-encapsulated sncRNA in regulating the host immune response might lead to the development of novel strategies for H. pylori vaccines.
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