Abstract
Brucella is a facultative intracellular pathogen able to invade and proliferate within a wide range of cell types. l-Serine biosynthesis is a major anabolic pathway in most organisms, but its contribution to Brucella persistence has not been characterized. In this issue, Révora et al. (e00840-19) show that disruption of the phosphorylated pathway for l-serine biosynthesis causes auxotrophy. The mutants can be internalized but are unable to proliferate intracellularly. Exogenous l-serine supplementation reverts auxotrophy and allows replication to resume. The results reveal a limited availability of l-serine within the host cell, highlighting the relevance of this biosynthetic pathway for Brucella pathogenesis.
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