Abstract
Poxviruses are exceptional in having a multicomponent entry-fusion complex (EFC) that is comprised of eleven conserved proteins embedded in the membrane of mature virions. Schin et al. (e00852-21) adapted the tripartite split green fluorescent protein complementation system to determine individual EFC protein contacts by proximity analysis within living cells. Previous EFC protein interactions were confirmed and new ones discovered and corroborated by additional methods. Most remarkable was the finding that the small, hydrophobic O3 protein interacted with each of the other EFC proteins, suggesting that multiple copies stabilize the complex within the viral membrane.
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