Abstract
Feline leukemia virus (FeLV) exists as both an endogenous component of the cat genome and a horizontally transmitted pathogen of felids. Chiu et al. (e00070-21) identified siRNA and miRNA LTR transcripts in RNA data sets generated from healthy, uninfected cats and found that these RNAs predominate in lymphoid tissues. This finding correlates with observations that endogenous LTR copy number is inversely related to FeLV susceptibility, suggesting that RNA interference contributes to interaction between exogenous-endogenous retroviral homologues.
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