Abstract
The host response to Borrelia burgdorferi causes the symptoms of Lyme arthritis. Little is known about the role of regulatory T (Treg) cells in controlling the development of this disease. Siebers et al. (e00160-20) demonstrate that depletion of Treg cells prior to infection with B. burgdorferi causes the development of arthritis 2 weeks later in an otherwise disease-resistant murine phenotype. Data suggest that depletion of Treg cells after infection may lead to more rapid joint inflammation. This study provides evidence that Treg cells are a critical host factor in controlling pathological outcomes of B. burgdorferi infection.
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