Abstract

Summary The therapeutic potential of oil from blends of selected culinary spices against artesunate-induced testicular injury in albino rats was investigated. Two groups of rats each were pretreated with the oil at 1.5 and 3.00 mL respectively for seven days and after which administered artesunate (100 mg/kg bw) for seven days; two other groups were administered artesunate for seven days and after which post treated with the oil at both doses respectively for another seven days; another groups were co-administered artesunate and the oil for seven days. A group was administered artesunate only for seven days, while another was fed chows only. After sacrifice, the testicular homogenates of the rats were analysed for GSH, Superoxide Dismutase (SOD), Catalase (CAT), Lipid peroxidation (LPO), 3β-HSD and 17β-HSD activities. LPO and GSH levels, SOD and CAT activities were significantly (p

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