Abstract
Total serum complement activity (CH50) was assayed in 8 healthy subjects, 352 consecutive patients, and 30 male patients who underwent diagnostic cardiac catheterization. Analyses of complement activity in the 8 healthy subjects revealed that the measured variation due to analytical error was quite small when compared with variation among subjects, variation due to sex, and variation due to the day of collection. Mean complement activity was higher in the 352 consecutive patients than in healthy subjects. Complement activity was greater in women than in men, but was highest and most variable in the 30 men undergoing cardiac catheterization. The average pulmonary arterial-systemic arterial (PA-A) complement activity difference measured in catheterized patients was small (−4.0 ± 32.1 CH50 units per ml); however, 5 patients had PA-A CH50 values that deviated from the mean for this group by more than two standard deviations. Three patients with documented recent pulmonary embolism had low mixed venous complem...
Published Version
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