Arteriolosclerosis Differs from Venular Collagenosis in Relation to Cerebrovascular Parenchymal Damages: An Autopsy-based Study (P3-6.010)

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<h3>Objective:</h3> We aimed to investigate the associations between microvascular injuries, including arteriolosclerosis and venular collagenosis, and related parenchymal damages in aging brains, to investigate the underlying correlations. <h3>Background:</h3> Cerebrovascular parenchymal damage is prevalent in aging brains; however, its vascular etiology has not been fully elucidated. In addition to the underlying role of sclerotic arterioles, the correlation between collagenized venules has not been clarified. <h3>Design/Methods:</h3> We evaluated arteriolosclerosis and venular collagenosis in seven regions from 27 autopsy cases with no history of stroke or brain tumor. The correlations between the ratio of arteriolosclerosis, venular collagenosis, and the severity of cerebrovascular parenchymal damage, including lacunes, microinfarcts, myelin loss, and parenchymal and perivascular hemosiderin deposits, were assessed. <h3>Results:</h3> Arteriolosclerosis and venular collagenosis became more evident with age. Arteriolosclerosis was associated with lacunes (p = 0.004) and brain parenchymal hemosiderin deposits in the superior frontal cortex (p = 0.024) but not with leukoaraiosis severity. Venular collagenosis was not associated with the number of lacunes or hemosiderin, while white matter generally became paler with severe venular collagenosis in the periventricular (β = −0.430, p = 0.028) and deep white matter (β = −0.437, p = 0.025). <h3>Conclusions:</h3> Our findings imply an important role for venular lesions in relation to microvessel-related parenchymal damage which is different from that for arteriolosclerosis. Different underlying mechanisms of both cerebral arterioles and venules require further investigation. <b>Disclosure:</b> Ms. Cao has nothing to disclose. Miss Huang has nothing to disclose. Dr. Mao has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Xu has nothing to disclose. Dr. Qian has nothing to disclose. Dr. Ma has nothing to disclose. Dr. Qiu has nothing to disclose. Yi-Cheng Zhu has nothing to disclose.