Abstract
Arteriogenesis, also frequently called collateral formation or even therapeutic angiogenesis, comprises those processes that lead to the formation and growth of collateral blood vessels that can act as natural bypasses to restore blood flow to distal tissues in occluded arteries [...].
Highlights
This Special Issue of Cells is devoted to all aspects of arteriogenesis, collateral formation and therapeutic angiogenesis
The role of inflammation and immune cells in arteriogenesis is illustrated by Bot el al., who extended the studies on the role of mast cells in arteriogenesis and collateral formation and demonstrated that local mast cell activation increased blood flow through the hind limb, due an increase in the diameter of the collaterals, as well as in the number of CD31+ capillaries
The induction of angiogenesis by vascular endothelial growth factor (VEGF) is well established, and the VEGF stimulation of endothelial cells encompasses a complex series of events that include the activation of various intracellular signaling cascades
Summary
This Special Issue of Cells is devoted to all aspects of arteriogenesis, collateral formation and therapeutic angiogenesis. Demonstrate that after the induction of hind limb ischemia in mice, the lipopeptide and TLR2/6 ligand macrophage-activating protein of 2-kDA (MALP-2) increased the growth of pre-existing collateral arteries in the upper hind limb, along with intimal endothelial cell proliferation in the collateral wall and pericollateral macrophage accumulation.
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