Abstract
Background In pilot studies, increased vascular tortuosity is associated with adverse outcomes in children and young adults withheritable thoracic aortic disease, specifically Marfan syndrome (MFS) and Loeys Dietz syndrome (LDS). It is known that vertebral artery tortuosity is highly prevalent in older adults who do not have heritable thoracic aortic disease. We hypothesized that tortuosity increases with age in patients with aortic disease <50 years old.
Highlights
In pilot studies, increased vascular tortuosity is associated with adverse outcomes in children and young adults withheritable thoracic aortic disease, Marfan syndrome (MFS) and Loeys Dietz syndrome (LDS)
Using linear longitudinal regression analysis, we evaluated the change in vertebral artery tortuosity index (VTI) per year overall and by diagnostic category
(54, range 14-235), followed by MFS; the lowest VTIs were in BAV and Turner syndrome (TS)
Summary
In pilot studies, increased vascular tortuosity is associated with adverse outcomes in children and young adults withheritable thoracic aortic disease, Marfan syndrome (MFS) and Loeys Dietz syndrome (LDS). It is known that vertebral artery tortuosity is highly prevalent in older adults who do not have heritable thoracic aortic disease. We hypothesized that tortuosity increases with age in patients with aortic disease
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