Abstract
ABSTRACT Objective The aim of this study is to evaluate and compare arterial stiffness, which is an independent risk indicator for cardiovascular diseases (CVDs), between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers with pulse wave analysis (PWA). Subjects and methods A total of 102 volunteers were included in the study (30 in the overt hyperthyroid group, 28 in the subclinical hyperthyroid group and 14 with euthyroidism by antithyroid therapy and 30 healthy). The arterial stiffness measurements of the participants in the study were performed with the Mobil-O-Graph PWA device (I.E.M. GmBH, Stolberg, Germany), which makes cuff based oscillometric measurement from the brachial artery. Results Systolic blood pressure, pulse rate, central systolic blood pressure, cardiac output, heart rate-corrected augmentation index (Aix@75) and pulse wave velocity (PWV) measurements were significantly higher in the hyperthyroid group than in the control group. The heart rate and PWV in the subclinical hyperthyroid group were significantly higher than the control group. In the euthyroid group, systolic blood pressure, central systolic blood pressure, cardiac output, cardiac index and PWV were found significantly higher than the control group. There was also a negative correlation between Aix@75 and thyroid-stimulating hormone (TSH), and a positive correlation between Aix@75 and free thyroid hormones. Conclusion In our study, we observed that the arterial stiffness was adversely affected by an overt or subclinical increase in thyroid hormones and this correlated with thyroid hormone levels. We recommend that PWV measurement, which is a simple method for detecting CVD risk, can be used in these patients.
Highlights
The endocrine system has a wide effect on the cardiovascular system
We found that there was an increase in the arterial stiffness and a significant correlation between Aix@75, the arterial stiffness parameter, and thyroid hormone levels
The relationship between thyroid hormone levels and arterial stiffness has become more current in recent years and has been investigated in some communitybased studies
Summary
The endocrine system has a wide effect on the cardiovascular system. In particular, the thyroid gland has a specific relationship with cardiovascular system physiology and pathology. In the light of all this information, our aim is to evaluate and compare arterial stiffness, which is an independent risk indicator for CVDs, between patients with overt hyperthyroidism, subclinical hyperthyroidism, euthyroidism by antithyroid therapy and healthy volunteers, with pulse wave analysis (PWA). Obuobie and cols., a first study of the relationship between thyrotoxicosis and arterial stiffness, found lower augmentation index in a small number (n = 20) of thyrotoxicosis cases than the control group during the diagnosis [13].
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