Abstract
Background NO-sensitive guanylyl cyclase (NO-GC) is the most important receptor for NO. The NO signal is transmitted through an increase in cGMP to act on several effector molecules. The NO/cGMP cascade is involved in the regulation of vessel diameter ultimately contributing to set the blood pressure. Lack of NO or NO-GC is thought to alter the responsiveness of blood vessels as well as their composition. We hypothesize that arterial stiffness may be altered in the absence of NO-GC.
Highlights
NO-sensitive guanylyl cyclase (NO-GC) is the most important receptor for NO
Lack of NO or NO-GC is thought to alter the responsiveness of blood vessels as well as their composition
We hypothesize that arterial stiffness may be altered in the absence of NO-GC
Summary
Arterial stiffness and collagen expression in mice lacking NO-sensitive guanylyl cyclase. Sarah Dünnes1*, Dieter Groneberg, Volker Herold, Peter Jakob, Andreas Friebe. From 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications Trier, Germany. From 7th International Conference on cGMP Generators, Effectors and Therapeutic Implications Trier, Germany. 19-21 June 2015
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