Abstract
Hypotensive effect of clonidine and its effect on arterial pressure lability as the main index of stability of background blood pressure are studied in intact spontaneously hypertensive rats (SHR) and rats with chronic sinoaortic denervation. Barodenervation potentiates hypotensive and negative cardiochronotropic effects of clonidine, which is accompanied by reduced blood pressure lability. This indicates an increased sensitivity of central α2-and imidazoline receptors, which mediate the depressor effect of clonidine, against the background of chronic inhibition of the baroreceptor reflex.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
