Abstract
OBJECTIVe. The article is devoted to the study of the safety and the effectiveness of the arterial chemoembolization in patients with locally advanced pancreatic cancer. MATERIAL AND METHODS. Between 2000 and 2015, 52 patients with unresectable locally advanced cancer of the pancreatic head without remote meastases T3-4n0-1M0 were treated with chemoembolization of the gastroduodenal artery. 109 cycles of chemoembolization (from 1 to 7, average 2) were performed. RESULTS. Manifestations of postembolization syndrome were stopped within 24 hours with conservative therapy. chemotherapeutic toxicity of I degree was observed in 44 (85 %) patients, gastrointestinal toxicity of II–III degree – in 8 (15 %). clinical effect such as increased body mass and reduction of pain was achieved after performing two cycles in the majority of patients: 90 and 71 %, respectively. The average life expectancy of the entire group was 9.9, median of 6.7 months. however, these figures were higher in14 patients received three or more cycles: 14.4 and 9.6 months. oily chemoembolization of the arteries of the pancreas is a relatively safe method of treatment in patients with inoperable cancer of the pancreas head. Performing of the multiple cycles increases patient survival.
Highlights
Arterial chemoembolization in patients with locally advanced pancreatic cancer Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St
The article is devoted to the study of the safety and the effectiveness of the arterial chemoembolization in patients with locally advanced pancreatic cancer
Between 2000 and 2015, 52 patients with unresectable locally advanced cancer of the pancreatic head without remote meastases T3-4N0-1M0 were treated with chemoembolization of the gastroduodenal artery. 109 cycles of chemoembolization were performed
Summary
Артериальная химиоэмболизация у больных местно-распространённым раком поджелудочной железы. Рассмотрена безопасность и эффективность применения артериальной химиоэмболизации у больных с местно-распространнным раком поджелудочной железы (ПЖ). Химиоэмболизацию гастродуоденальной артерии провели у 52 больных с нерезектабельным местно-распространнным раком головки поджелудочной железы без отдаленных метастазов T3-4N0-1M0. Однако у 14 больных, получивших три и более циклов, эти показатели были выше: 14,4 и 9,6 мес. Масляная химиоэмболизация артерий поджелудочной железы является относительно безопасным методом лечения больных неоперабельным раком головки ПЖ. Цель исследования – дальнейшая оценка без опасности и эффективности МХЭ у больных с местно-распространённым РПЖ. В РНЦРХТ получали лечение 507 больных РПЖ с использованием регионарной химиотерапии как в виде самостоятельного противоопухолевого лечения (n=291; 57 %), так и в комбинации с другими методами: радикальная операция (n=178; 35 %), лучевая терапия (n=37; 8 %). МХЭ как единственный метод лечения использовали у 52 больных нерезектабельным местно-распространённым раком головки ПЖ без отдаленных метастазов T3-4N0-1M0.
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