Abstract
Arterial P O 2 , P CO 2 and pH, as well as lactate and pyruvate concentrations, were measured in unanaesthetized rats exposed to air or to gas mixtures containing from 15.30 to 5.07% O 2 for 5 to 30 min. In air-breathing controls the Pa O 2 was 91 mm Hg, Pa CO 2 41 mm Hg and pH 7.43. With reduction in inspired O 2 the Pa O 2 decreased to minimal values of 21 mm Hg (5% O 2), the Pa CO 2 tell to minimal values of 13 to 14 mm Hg (5% O 2) and the pH increased to maximal values of 7.661 (7% O 2). The decrease in Pa CO 2 and increase in pH occurred already at 15.3% O 2. With 5% O 2 there was a marked but variable nonrespiratory acidosis that either limited the alkaline shift in pH, or caused a net acid shift in pH. Accumulation of lactate occurred with 13% O 2, and with 11% O 2 there was an increase in lactate/pyruvate ratio. However, a significant pyruvate accumulation occurred only when the inspired O 2 was decreased to less than 7%.
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