Abstract
Artemisia judaica Attenuates Hyperglycaemia-Mediated Oxidative Stress and Cardiac Injury in Streptozotocin-Induced Diabetic Rats
Highlights
Diabetes mellitus (DM) is a metabolic disorder characterised by hyperglycaemia and associated with numerous acute and chronic complications such as nephropathy, retinopathy and cardiomyopathy
Judaica improves body weight and ameliorates hyperglycaemia in type I diabetic rats As shown in Figure 1A-D, diabetic rats showed a significant decrease in body weight, increased glucose and HbA1c levels and decreased insulin levels
Necrosis of pancreatic β-cells and induction of type 1 diabetic rats after STZ administration is attributed to over production of hydrogen peroxide and hydroxyl radicals causing oxidative damage to DNA and cell membrane in addition to induction of protein glycation in the susceptible pancreatic β-cells which are characterized by low antioxidants enzymes.[33]
Summary
Diabetes mellitus (DM) is a metabolic disorder characterised by hyperglycaemia and associated with numerous acute and chronic complications such as nephropathy, retinopathy and cardiomyopathy. (A. judaica) belongs to the family Asteraceae and Artemisia genera which are widely used in folk medicine being recommended by Bedouins in Middle Eastern countries where it is known by the Arabic name “Al-ba'atharan”.6 It is widely used for the treatment of gastro-intestinal disorders, heart diseases, erectile dysfunction, diabetes mellitus, wound healing, and inflammatory related diseases such as arthritis.7Extracts and isolated compounds from A. judaica have exhibited various biological and Medicinal characteristics including antibacterial, antifungalinsecticidal, antioxidant, and antidiabetic effects.[8,9] In agreement with the traditional use of A. judaica for the treatment of gastrointestinal disorders, cirsimaitin, the flavone isolated from A. judaica, inhibited the amplitude of the phasic contractions and reduced the tone of guinea-pig ileum.[10]. Official Journal of Natural Product Research Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
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