Abstract
Artemeriosides A–F (1–6), six novel sesquiterpenoids containing a 6′-O-crontonyl β-glucopyranoside, were isolated from Artemisia annua L. Their structures were determined by spectral data including HRESIMS, IR, UV, 1D and 2D NMR, and ECD calculations. Compounds 1–6 represented the first examples of natural sesquiterpenoid substituted by 6′-O-crontonyl β-glucopyranoside. By antihepatoma assay, compounds 1 and 2 demonstrated inhibitory effect against both HepG2 and SK-Hep-1 cells with inhibitory ratios of 77.0%, 88.8%, and 86.8%, 83.9% at 200.0 μM, and compound 1 showed inhibitory activity against Huh7 cells with inhibitory ratio of 56.8%.
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