Artemdubosides A-G, seven unusual polyacetylenes from Artemisia dubia var. subdigitata and their antihepatoma activity

Abstract

Artemdubosides A-E (1–5), the first examples of natural polyacetylenes substituted by 6’-O-crotonyl β-glucopyranoside, and artemdubosides F-G (6–7) that were two unusual polyacetylenes featuring a 6’-O-acetyl β-glucopyranoside moiety, were isolated from Artemisia dubia var. subdigitata. Their structures were elucidated based on the spectral data including HRESIMS, UV, IR, 1D and 2D NMR, and ECD calculations. Antihepatoma assay suggested that compound 1 exhibited activity against HepG2, Huh7, and SK-Hep-1 cells with inhibitory ratios of 77.1%, 90.8%, and 73.1% at 200.0 μM, respectively.