Abstract
We evaluated the combined effect of As2O3 and ionizing radiation on cultured renal carcinoma cells. The cells receiving both As2O3 and radiotherapy had more DNA damage, more apoptosis, more reactive oxygen species produced, more cells in G2/M phase, and a lower mitochondrial membrane potential than cells treated with As2O3 only or with radiotherapy only (for all comparisons, p < .05). Renal carcinoma cells can be sensitized to ionizing radiation with As2O3, and combining As2O3 and radiation had larger effects than As2O3 only or radiation only.
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