Arsenic toxicity and carcinogenesis: a public health risk assessment and management approach

Abstract

Acute and chronic exposure to arsenic has been reported in several countries of the world, with major outbreaks of arsenosis occurring in Argentina, Bangladesh, India, Mexico, Thailand, and Taiwan, where a large proportion of drinking water (groundwater) is contaminated with high concentrations of arsenic. Research has also pointed to significantly higher standardized mortality rates for cancers of the bladder, kidney, skin, liver, and colon in many areas of arsenic pollution. There is therefore a great need for developing a comprehensive risk assessment model that should be used in the effective management of health risks associated with arsenic exposure. With a special emphasis on arsenic toxicity and carcinogenesis, this paper aims at developing and presenting a conceptual risk assessment and management model. Using the National Academy of Science’s risk assessment and management framework as a guide, all critical information has been analyzed and presented with respect to the health hazard, the sources and pathways of human exposure, the concept of the dose–response relationship in arsenic poisoning, the characterization of both systemic and carcinogenic effects, and the potential strategies to control and/or prevent arsenic poisoning.