Arsenic-induced Histological Alterations in Various Organs of Mice.

Abu Shadat Mohammod

doi:10.4172/2157-7099.1000323

Abstract

Deposition of arsenic in mice through groundwater is well documented but little is known about the histological changes of organs by the metalloid. Present study was designed to evaluate arsenic-induced histological alterations in kidney, liver, thoracic artery and brain of mice which are not well documented yet. Swiss albino male mice were divided into 2 groups and treated as follows: Group 1: control, 2: arsenic (sodium arsenite at 10 mg/kg b.w. orally for 8 wks). Group 2 showed marked degenerative changes in kidney, liver, thoracic artery, and brain whereas Group 1 did not reveal any abnormalities on histopathology. We therefore concluded that arsenic induces histological alterations in the tested organs.

Highlights

Around 200 million people (NRC 2001) worldwide are at risk from health effects associated with high concentrations of arsenic in their drinking water [1]
There were some alterations of morphological structure in arsenic exposed mice thoracic artery than normal tissue
Arsenic mediated oxidative stresses are indicated for changing the organ degeneration during exposure

Summary

Introduction

Around 200 million people (NRC 2001) worldwide are at risk from health effects associated with high concentrations of arsenic in their drinking water [1]. Chronic exposure to inorganic arsenic (iAs) that occurs as a natural contaminant in drinking water is associated with the development of skin cancer [2,3] and other severe health problems such as diabetes, liver, kidney, CNS disorders [4] and causes many other toxic effects [5,6]. Still there is no report describes the histological effect of arsenic on some organs such as artery, and brain where as other organs like kidney and liver are not well defined. This study was designed to evaluate the histological changes by chronic arsenic exposure on some tissue architecture in mice. A better understanding of the effect of arsenic at target organs with an emphasis on observation of tissue architecture at critical sites will aid in defining a mode(s) of action for arsenic-induced toxicity in mammals and reduce the uncertainty in the risk assessment for this metalloid

Methods

Results

Conclusion