Abstract
Cervical cancer is the second most common gynecological malignancy worldwide. According to HPV Information Centre, Spain (Aug'2014), in India approximately 1,22,844 women are diagnosed with the disease every year and of them 67,477 die due to the disease. CaCx is said to be mediated by HPV but recent data published reveal the role of Oxidative Stress in different Cancers. Arsenic is also one of the agents for causing Oxidative Stress. Arsenic has been linked with different types of cancer. Arsenic is considered responsible for generation of free radicals and eventually for apoptosis. Early diagnosis of CaCx is presently a matter of concern and clinical presentation in advanced stages become difficult for complete clinical response. For determination of oxidative stress, Malondialdehyde (MDA) was taken as an identifier and arsenic estimation was performed with the help of Atomic Absorption Spectrometer (AAS). RBC count and Haemoglobin levels were performed according to standard protocol. MDA was in direct proportion with arsenic concentration and inversely proportional to RBC and Haemoglobin in CaCx patients. Arsenic is one of the major causative agents for oxidative stress and hence may be a risk factor leading to cancer including CaCx.
Highlights
Introduction5,00,000 new cases are diagnosed every year with a higher rate of incidence among women of lower socioeconomic status especially in developing countries (Bray et al, 2005)
Cervical cancer is one of the most common gynecological malignancy worldwide
Carcinoma of Cervix (CaCx) is said to be mediated by Human Papilloma Virus (HPV) but recent data published reveal the role of Oxidative Stress in different Cancers
Summary
5,00,000 new cases are diagnosed every year with a higher rate of incidence among women of lower socioeconomic status especially in developing countries (Bray et al, 2005). 1,22,844 women are diagnosed every year with cervical cancer and out of them 67,477 die from the disease. India has a population of 432.20 million women aged 15 years and older who are at the risk of developing Cervical Cancer. It is a multifactorial disease and several risk factors include Human Papilloma Virus (HPV) infection, early age of intercourse, multiple sex partners, smoking, oral contraceptive use and low socioeconomic status (Barrionuevo - Rosas et al, 2014). The imbalance between the pro-oxidants and antioxidants towards pro-oxidants is called Oxidative
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