Abstract
The effects of gonyautoxins (GTXs), the major component of paralytic shellfish poison in Japan, on cardiovascular system in rabbits were examined by means of the electrocardiogram (ECG) pattern and the arterial pressure changes. The intravenous administration of GTXs produced transient arrhythmia and hypotension. GTXs induced prolongation of P-R and QRS intervals in the ECG, which was prone to initiate paroxysmal ventricular tachycardia, fibrillation and flutter in a large amount of GTXs. Similar results were observed in vagotomized rabbits.
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