Abstract
Coronavirus disease 2019 (COVID-19) has been associated with cardiac arrhythmias. Several electrocardiographic markers have been used to predict the risk of arrhythmia in patients with COVID-19. We aim to investigate the electrocardiographic (ECG) ventricular repolarization indices in patients with COVID-19. We performed a comprehensive systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and Google Scholar Preprint Servers. The primary endpoints of this search were: Tp-e (T-peak-to-T-end) interval, QTd (QT dispersion), and Tp-e/QTc ratio in patients with newly diagnosed COVID-19 from inception up until August 2020. There were a total of 241 patients from 2 studies. Meta-analysis showed that Tp-e/QTc ratio was higher in COVID-19 group (mean difference 0.02 [0.01, 0.02], p < 0.001; I2: 18%,). Tp-e interval was more prolonged in COVID-19 group (mean difference 7.76 [3.11, 12.41], p < 0.001; I2: 80%) compared to control group. QT dispersion (QTd) also was increased in COVID-19 group (mean difference 1.22 [0.61, 1.83], p < 0.001 ; I2:30%). Several electrocardiographic markers including Tp-e/QTc, Tp-e interval, and QTd are significantly increased in patients with COVID-19.
Highlights
Coronavirus disease 2019 (COVID-19) has been associated with cardiac arrhythmias
Meta-analysis showed that Tp-e/QTc ratio was higher in COVID-19 group
Tp-e interval was more prolonged in COVID-19 group compared to control group
Summary
Several electrocardiographic markers have been used to predict the risk of arrhythmia in patients with COVID-19. We aim to investigate the electrocardiographic (ECG) ventricular repolarization indices in patients with COVID-19. Arrhythmias were observed in 19% of COVID-19 patients, according to a recent meta-analysis, and their presence was associated with a poorer outcome [7]. Some novel electrocardiography (ECG) markers, such as Tpeak-to-Tend (Tp-e), QT dispersion (QTd), and Tpe/QT ratio have been shown to reflect transmural ventricular dispersion of repolarization or the repolarization heterogeneity and defined as predictors of risk for ventricular arrhythmias and sudden cardiac death in various clinical settings, including myocarditis [8,9,10]. This systematic review and meta-analysis aimed to evaluate ventricular repolarization parameters in treatment-naive COVID-19 patients compared to healthy individuals
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