Abstract
Through a process of selection in an isolate of O. cuniculi, the propensity for arrested development in response to cold treatment was increased from 15 to over 90% in five generations. In subsequent generations, the propensity for arrest remained high so long as selection pressure was maintained. The selected high arresting isolate exhibited a corresponding increase in ability to arrest without prior cold treatment of infective larvae. In the absence of selection for arrest, this isolate reverted to one with a lower propensity for arrest. These results indicate that arrested development has a genetic basis. A hypothesis was developed which proposed that continuous variation in the rate of development is controlled by polygenes and that a worm will exhibit arrested developmet if its genotype has an enrichment of alleles for slow growth at the various polygenic loci.
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