Abstract
Rapid, high-resolution analysis of genomic rearrangements has become possible using array-comparative genomic hybridization (aCGH), a combination of CGH with DNA microarray technology. Using aCGH, genome copy number changes and rearrangement breakpoints can now be mapped and analyzed at resolutions down to a few kilobases or even less in a single hybridization. This technology is enabling us to identify previously hidden rearrangements in patients with suspected genomic disorders for which no karyotype aberrations could be identified using conventional cytogenetic analysis. Furthermore, the development of array painting has revealed a surprising level of rearrangement complexity in patients with apparently balanced translocations.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
