Arousal and T-maze choice behavior in mice: A convergent paradigm for neophobia constructs and optimal arousal theory

Abstract

Three experiments investigating the effects of arousal on the T-maze choice behavior of inbred mouse strains are reported. In Experiment 1, CBA and NZB mice were administered unrewarded free choice alternation tests on 10 consecutive days under either No Shock, Shock Start (shocked in the start box), or Shock Choice (shocked at the choice point) treatment conditions. Both strain and treatment effects were observed: In the No-Shock condition, the nonreactive CBA strain alternated, but the reactive NZB strain did not. In the Shock Start condition the CBA strain showed only a suppressed alternation, while the NZB strain administered the same treatment perseverated. Both strains perseverated in the Shock Choice condition. In Experiment 2, NZB mice administered identical shocks in the start box and goal arms on both trials of five consecutive tests conducted once a day perseverated to the same goal arm in which they had been shocked on the first trial. In Experiment 3, NZB mice punished for perseverating (with shock continuation) and simultaneously reinforced for alternating (with shock termination) showed a “punishment paradox”; they perseverated despite the reinforcement contingencies. These results, which are congruent with the optimal arousal theory and several characteristics the theory shares with the emergent neophobia construct, support the contention that arousal mediates a symmetrical relationship between approach and avoidance along a novelty-familiarity continuum.