Abstract
Aromatic DNA adduct levels were determined by the 32P-postlabelling assay in lymphocytes isolated from newspaper vendors working at urban high traffic areas ( n = 31) and suburban low traffic areas ( n = 22) in Milan, Italy. The DNA adduct levels ranged from 0.7 to 6.7 10 8 nucleotides, while most of them were between 1.0 and 3.0 10 8 nucleotides. No difference was found between the DNA adduct levels of the high-exposed group ( 2.2 10 8 ) and the low-exposed group ( 2.2 10 8 ). The heavy smokers ( n = 8) had 23% higher DNA adduct level ( 2.7 10 8 ) than the non-smokers ( n = 37, 2.2 10 8 ) ( P = 0.27), but no correlation was found between the adduct level and the number of cigarettes/day. Analysis of variance of the DNA adduct levels among the 14 pairs of individuals working at the same news-stands revealed little effect of the environmental air exposure on the DNA adduct level.
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