Abstract
19-Oxoandrostenedione, the product of 19-hydroxyandrostenedione by the 19-oxidase activity of the purified P-450 11 β system of adrenal cortex mitochondria, was further oxidized and demethylated at the 10-position to give the C 18-steroids, estrone (aromatase reaction) and 19-norandrostenedione (nonaromatizing 10-demethylase or C10–19 lyase reaction). These reactions, together with the initial hydroxylation of androstenedione at C19, form a sequence of P-450 11β-catalyzed C 19-steroid 19-monooxygenase reactions. P-450 11 β is thus similar to placental endoplasmic P-450 AROM in some of its substrate specificity, but the two forms of P-450 appear to be different in both physiology and properties.
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