Abstract
Armadillo gene subfamily members (ARMCX1-6) are well-known to regulate protein-protein interaction involved in nuclear transport, cellular connection, and transcription activation. Moreover, ARMCX signals on cell pathways also implicated in carcinogenesis and tumor progression. However, little is known about the associations of the ARMCX subfamily members with gastric carcinoma. This study investigated the prognostic value of ARMCX subfamily mRNA expression levels with the prognosis of gastric carcinoma (GC). We retrieved the data of a total of 351 GC patients from TCGA database. Survival and gene set enrichment analyses were employed to explore the predictive value and underlying mechanism of ARMCX genes in GC. The multivariate survival analysis revealed that individually low expressions of ARMCX1 (adjusted P = 0.006, HR = 0.620, CI = 0.440 − 0.874) and ARMCX2 (adjusted P = 0.005, HR = 0.610, 95%CI = 0.432–0.861) were related to preferable overall survival (OS). The joint-effects analysis shown that combinations of low level expression of ARMCX1 and ARMCX2 were correlated with favorable OS (adjusted P = 0.003, HR = 0.563, 95%CI = 0.384–0.825). ARMCX1 and ARMCX2 were implicated in WNT and NF-kappaB pathways, and biological processes including cell cycle, apoptosis, RNA modification, DNA replication, and damage response. Our results suggest that mRNA expression levels of ARMCX subfamily are potential prognostic markers of GC.
Highlights
Gastric carcinoma, one common type of malignant tumors, is the fifth highest incidence and the second highest mortality after lung cancer worldwide [1]
ARMCX4 were lowly expressed in primary gastric tumors (a, b, d)
By analyzing the TCGA data, the results have shown that only ARMCX1 and ARMCX2 had statistical significance
Summary
One common type of malignant tumors, is the fifth highest incidence and the second highest mortality after lung cancer worldwide [1]. The poor prognosis is due to a high incidence of advanced disease, high recurrence rate, high metastasis, and abnormal gene expression. New strategies to improve diagnosis and prognosis of gastric cancer are shortly needed. More and more related proteins have been identified and classified as armadillo repeat family. The common feature of these proteins is an amino acid sequence (arm repeats) approximately 42 residues, identified as 6-13 repeat units in all members of the family [5, 6], and each repeat domain consists of three helices, designated as H1, H2, and H3 [7,8,9]
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