Abstract
Alkaloids derived from plants have shown great medicinal benefits, and are often reported for their use in cardiovascular disease management. Aristotelia chilensis (Molina) Stuntz (Maqui) has shown important medicinal properties in traditional useage. In this study, we evaluated the effect of the indole-alkaloid aristoteline (ARI), isolated from leaves of Maqui, on vascular reactivity of isolated aortic rings from normotensive rats. ARI induced relaxation (100%) in a concentration-dependent manner in intact or denuded-endothelium aortic rings pre-contracted with phenylephrine (PE; 1 μM). However, a specific soluble guanylyl cyclase inhibitor (ODQ; 1 μM) significantly reduced the relaxation to ARI in aortic rings pre-contracted with PE. In the presence of ARI, the contraction induced by KCl or PE was significantly (p < 0.05) decreased. Interestingly, the potassium channel blockade with 10 μM BaCl2 (Kir), 10 μM glibenclamide (KATP), 1 mM tetraethylammonium (TEA; KCa1.1), or 1 mM 4-aminopyridine (4-AP; Kv) significantly (p < 0.05) reduced the ARI-induced relaxation. ARI significantly (p < 0.05) reduced the contractile response to agonist of CaV1.2 channels (Bay K8644; 10 nM), likely reducing the influx of extracellular calcium through plasma membrane. The mechanisms associated with this process suggest an activation of the potassium channels, a calcium-induced antagonism and endothelium independent vasodilation that possibly involves the nitric oxide-independent soluble guanylate cyclase pathway.
Highlights
Aristoteline (ARI) is an indole-alkaloid derived from Aristotelia chilensis (Molina) Stuntz, a tree
The results obtained suggest for the first time the vasodilator proprieties of ARI, an isolated indole-alkaloid from Aristotelia chilensis (Molina) Stuntz (Maqui berry) leaves
ARI-induced an independent relaxation of the endothelium, which involves the activation of the ARI-induced an independent relaxation of the endothelium, which involves the activation of the potassium channels, and the reduction of the calcium influx through CaV 1.2
Summary
Aristoteline (ARI) is an indole-alkaloid derived from Aristotelia chilensis (Molina) Stuntz, a tree. Elaeocarpaceae family that is endemic to Chile and popularly known as the Maqui berry [1]. Is an indole-alkaloid derived from Aristotelia (Molina) Stuntz, a tree. The fruits and leaves of A. chilensis have shown an important range of chilensis biological properties including of the Elaeocarpaceae family that is endemic to. Maqui berry antioxidant [2], anti-inflammatory [3] and analgesic effects [4]. Leaf extracts have been used [1]. Leaf extracts have been used [1]. in
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
