Abstract
This essay looks at the historical significance of three APS classic papers that are freely available online: Leão AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 359–390, 1944 ( http://jn.physiology.org/cgi/reprint/7/6/359 ). Leão AAP. Pial circulation and spreading depression of activity in the cerebral cortex. J Neurophysiol 7: 391–396, 1944 ( http://jn.physiology.org/cgi/reprint/7/6/391 ). Leão AAP. Further observations on the spreading depression of activity in the cerebral cortex. J Neurophysiol 10: 409–414, 1947 ( http://jn.physiology.org/cgi/reprint/10/6/409 ).
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