Aripiprazole-loaded in Soft Lipidic Non-Lamellar Liquid Crystalline Nanostructures

Abstract

Event Abstract Back to Event Aripiprazole-loaded in Soft Lipidic Non-Lamellar Liquid Crystalline Nanostructures Intan Diana Mat Azmi1* and Lai Y. Khen1 1 Putra Malaysia University, Malaysia Background Non-lamellar liquid crystalline (LC) nanostructures have recently received attention in application in drug delivery systems, due to their unique well-defined and tunable internal nanostructures. The rich polymorphism of LC nanostructures are considered as a key factor in improving loading efficiency of different types of poorly soluble therapeutic agents. This project is focused on developing Aripiprazole-loaded non-lamellar LC nanostructures, consisted of a binary mixture of soy phosphatidylcholine (SPC) and citric acid ester of monoglyceride (citrem). Aripiprazole is a psychotropic drug that used to treat schizophrenia and bipolar disorder, which showed poor aqueous solubility of less than 0.3 μg/ ml. It is utmost interest to see the potential of non-lamellar LC nanoparticles in improving the loading efficiency of Aripiprazole by entrapping the drugs into their well-order internal nanostructures. Methods The investigated drug-free and drug-loaded nanodispersions were prepared based on a lipid ratio of SPC:Citrem (1:1 wt/wt) at 5 wt% lipid concentration via high energy ultrasonication. The characterizations were done to determine the particle size, stability, morphology, encapsulation efficiency and the interaction between the drugs and the nanodispersions. Results The results show that Aripiprazole, at three different concentrations (0.1, 0.2, and 0.25 wt%), were successfully loaded into LC nanoparticles where the encapsulation efficiency was all above 92%. The particle size of LC nanoparticles produced was in the range of 154.1-183.4nm, with polydispersity index, PDI 0.103-0.172, and zeta potential of -26.0mV to -29.1mV. Differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) showed that there was a chemical interaction between Aripiprazole and LC nanoparticles, while Transmission Electron Microscopy (TEM) was used to see the morphology and overall size distribution of drug-free and drug-loaded nanodispersions. Conclusion This study suggests the potential use of non-lamellar LC nanodispersions as a promising nanocarrier for Aripiprazole delivery, which is expected to improve the pharmacokinetics and stability of this drug. Acknowledgements Authors would like to thank Universiti Putra Malaysia for the IPM grant. Keywords: Liquid crystalline nanostructures, aripiprazole, Drug delivery, Schizophrenia, Nanoparticle (NP) Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Mental health Citation: Mat Azmi I and Khen LY (2019). Aripiprazole-loaded in Soft Lipidic Non-Lamellar Liquid Crystalline Nanostructures. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00050 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Oct 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Intan Diana Mat Azmi, Putra Malaysia University, Seri Kembangan, Malaysia, intandiana@upm.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Intan Diana Mat Azmi Lai Y Khen Google Intan Diana Mat Azmi Lai Y Khen Google Scholar Intan Diana Mat Azmi Lai Y Khen PubMed Intan Diana Mat Azmi Lai Y Khen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.