Abstract
The value of argyrophilic nuclear organiser region (AgNOR) counts in assessing histologically the effects of combination chemotherapy given to eleven patients with locally advanced breast cancer before mastectomy was studied. AgNOR counts were significantly reduced ( P < 0.001) in the post-chemotherapy, surgically excised residual tumour specimens compared with the initial diagnostic biopsy specimens. AgNOR counts could be used to monitor the effects of chemotherapy on breast cancer.
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