Abstract
Argiopin, a low-molecular weight component of the spider Argiope lobata venom, inhibited depolarizations of motoneurones induced by glutamate in experiments on the frog isolated spinal cord, but had no effect on aspartate-induced responses. Half of the blocking effect (ED50) was seen at 7.5 +/- 3.7 x 10(-8) M argiopin. The same concentrations of argiopin (7.5 x 10(-8) M to 2.3 x 10(-7) M) suppressed the responses of the ventral root to electrical stimulation of the dorsal root. The results suggest that argiopin selectively blocks only one population of the excitatory amino acid receptors on motoneurones, and these argiopin-sensitive receptors are found to be involved in sensorimotor synaptic transmission in the spinal cord.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
