Abstract
Specific binding sites for arginine-vasopressin (AVP) were detected in rat brain after incubation of tissue sections with [ 3H]AVP. AVP and two selective AVP antagonists are capable of displacing [ 3H]AVP with an IC 50 in the 10 −8–10 −7 molar range, while oxytocin and ACTH 4–10 were much less effective. The neuroanatomical distribution of [ 3H]AVP-labeled sites was studied with autoradiography utilizing tritium-sensitive LKB film and computerized densitometry for quantitative analyses of the film images. The highest density of [ 3H]AVP binding sites was observed in hippocampal regions, the lateral septum, olfactory and amygdaloid nuclei, and the nucleus tractus solitarii (NTS) of the brainstem.
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