Abstract
Background TP53 gene is one of the most important tumor suppressor genes. We undertook this meta-analysis to explore the association between TP53 Arg72Pro polymorphism and the risk of skin cancer mainly in Caucasians.MethodsWe searched PubMed for case-control studies published up to March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association.ResultsA total of 5276 skin cancer cases and 5315 controls from 20 studies were included. Overall, no significant association between TP53 Arg72Pro polymorphism and skin cancer was observed in all genetic contrast models (Pro/Pro versus Arg/Arg, Pro/Arg versus Arg/Arg, Pro/Pro + Pro/Arg versus Arg/Arg, Pro/Pro versus Arg/Arg + Pro/Arg, Pro allele versus Arg allele). Similar results were obtained in the stratified analysis by ethnicity and histological types of skin cancer, such as melanoma, squamous cell carcinoma and basal cell carcinoma. Power calculations indicated that some studies were underpowered. No publication bias was found by using the funnel plot and Egger's test.ConclusionsThis meta-analysis indicated that TP53 Arg72Pro polymorphism probably had little association with skin cancer susceptibility mainly in Caucasians. However, larger sample-size studies are required to verify the conclusion as low statistical powers.
Highlights
IntroductionSkin cancer including melanoma and non-melanoma is the most common type of cancer in white populations [1]
According to epidemiology, skin cancer including melanoma and non-melanoma is the most common type of cancer in white populations [1]
Inclusion Criteria The selected studies must have met the following major criteria: (1) well-designed case-control studies to evaluate TP53 Arg72Pro polymorphism and the risk of skin cancer; (2) skin cancer was diagnosed by pathology; (3) containing useful genotype frequencies; and (4) the distribution of genotypes among controls were in Hardy-Weinberg equilibrium
Summary
Skin cancer including melanoma and non-melanoma is the most common type of cancer in white populations [1]. TP53 gene is a tumor suppressor gene which can regulate cell cycle arrest, cell apoptosis and DNA repair [8]. TP53 gene is one of the most important tumor suppressor genes We undertook this meta-analysis to explore the association between TP53 Arg72Pro polymorphism and the risk of skin cancer mainly in Caucasians. Similar results were obtained in the stratified analysis by ethnicity and histological types of skin cancer, such as melanoma, squamous cell carcinoma and basal cell carcinoma. Conclusions: This meta-analysis indicated that TP53 Arg72Pro polymorphism probably had little association with skin cancer susceptibility mainly in Caucasians. Larger sample-size studies are required to verify the conclusion as low statistical powers
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
