Abstract
Regulators of Arf activity include a family of proteins with a shared domain, the cysteine-rich Arf GAP domain, that is responsible for activating the latent GTPase activity of Arfs. The first of these to be discovered, Arf GAP1 is the focus of this chapter. It’s role in the cellular actions of Arfs, particularly vesicular traffic, and the regulation of Arf GAP1 by other factors, e.g., lipids, is discussed.
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