Abstract
Odontogenic tumors (OT) are considered rare events and their epidemiologic data are scarce and under-estimated in developing countries because there is no systematic collection of clinical features including histological analyses of the tissue samples. Furthermore, there is an underestimation of the disease relevance and affected people are often marginalized in spite of severe functional impairment of aero-digestive tract. Etiology of OT in humans is still unknown and it represents an important therapeutic and diagnostic challenge.Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus, a member of the arenavirus family of viruses. The disease is endemic in the rodent population in West-East Africa. Humans usually become infected with Lassa virus through exposure to the food or household items contaminated with urine or feces of infected rats. It is also reported person-to-person infections. About 80% of people infected by Lassa virus have no symptoms but the virus establishes a life-long persistent infection.The present commentary significance is to start, for the first time ever, a systematic collection of clinical features and tissue sample collection at the St. Mary’s Hospital in Lacor (Gulu) North Uganda where the considered pathologies have an important frequency. The systematic collection will allow to corroborate the possible association between arenaviruses infection and pathogenesis of odontogenic tumors in humans.
Highlights
BackgroundOdontogenic tumors (OTs) are uncommon neoplastic lesions of the maxilla and mandible, which present difficult diagnosis and therapeutics
Mary’s Hospital in 2018, the volunteer medical staff documented 47 cases of Odontogenic tumors (OT) in the female patients ranging from 7 months to 64 years old (Fig. 1g), and 22 cases of OTs in the male patients ranging from 7 months to 6 years old (Fig. 1h)
Exhaustion was originally identified in CD8+ T cells (TEX) during lymphocytic choriomeningitis virus (LCMV, belonging to mammarenavirus) infection and subsequently in humans with HIV, hepatitis C virus (HCV), hepatitis B virus (HBV), and cancer [6, 9]
Summary
Odontogenic tumors (OTs) are uncommon neoplastic lesions of the maxilla and mandible, which present difficult diagnosis and therapeutics. The majority of these lesions represent real neoplasms with a subgroup of them characterized by invasive behavior. Among the OTs, it was documented in the sub-saharan local population cases regarding ossifying fibromas, ameloblastomas, fibrous dysplasia and odontogenic fibromixoma, which cause devastating facial deformations of children and young adults [3]; the surgical intervention leaves deformed faces condemning patients to the isolation. A systematic serological survey in the Uganda Karamoja District supported the presence of Lassa virus infections in that district population [7]
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